Professor Michael Fagan BSc, PhD, CITP, CEng, MBCS

Professor of Medical and Biological Engineering

Email:

Phone: +44 1482 465058

Web: http://www.hull.ac.uk/mbe/

Research Interests

• Modelling and simulation in medical and biological engineering
• Computational mechanobiology
• Understanding the form and function of bone
• The biomechanics of skulls
• Computer assisted diagnostics
• Speech restoration post-laryngectomy
• Medical device development

Current And Recently Completed Projects

• Simulation of tissue differentiation and integration in bone cell-seeded scaffolds (EPSRC HEC studentship)
• Modelling of the bone remodelling cycle and the osteocyte network and its control on mechanotransduction (EPSRC EP/E057365/1)
• Modelling the biomechanics and evolution of tetrapod skulls (BBSRC BB/E009204/1)
• Investigation into the mechanical function of the primate craniofacial skeleton (BBSRC BB/E014259/1)
• Modelling of tissue differentiation and adaptation around orthopaedic implants (Royal Society Fellowship)
• Recognition and reconstruction of speech following laryngectomy (Action Medical Research)
• Development of a second generation traceho-oesophageal fistula speech valve (Dept of Health J029)
• Understanding the development of the trabeculae in the human pelvis
• Predicting the risk of rupture of abdominal aortic aneurysms
• The effect of MMPs on the biomechanical properties of aneurysm wall tissue (MRC G0401470)
• The biomechanics of primate facial architecture (Leverhulme Trust F/00224/1)

Recent Publications

Published papers

• M Moazen, N Curtis, SE Evans, P O'Higgins, MJ Fagan. Combined finite element and multibody dynamics analysis of biting in a Uromastyx hardwickii lizard skull. Accepted for publication, Journal of Anatomy.
• M Moazen, N Curtis, P O'Higgins, MEH Jones, SE Evans, MJ Fagan Assessment of the role of sutures in a lizard skull - a computer modelling study. Accepted for publication, Proceedings of the Royal Society. DOI: 10.1098/rspb.2008.0863
• RC Griffin, H Moody, KEH Penkman, MJ Fagan, N Curtis, MJ Collins. A new approach to amino acid racemization in enamel: testing of a less destructive sampling methodology. Journal of Forensic Sciences, 53:4, 910-916, 2008.
• M Moazen, N Curtis, S Evans, P O'Higgins, MJ Fagan. Rigid body analysis of the lizard skull: modelling the skull of Uromastyx hardwickii. Journal of Biomechanics, 41:6, 1274-1280, 2008.
• MJ Fagan, SR Ell, JM Gilbert, E Sarrazin, PM Chapman. Development of a (silent) speech recognition system for patients following laryngectomy. Medical Engineering and Physics, 30:4, 419-425, 2008.
• N Curtis, K Kupczik, P O'Higgins, M Moazen, MJ Fagan. Predicting skull loading: applying multibody dynamics analysis to a macaque skull. The Anatomical Record, 291, 491-501, 2008.
• K Mazik, N Curtis, MJ Fagan, S Taft, M Elliott. Accurate quantification of the influence of benthic macro- and meio-fauna on the geometric properties of estuarine muds by micro computer tomography. Journal of Experimental Marine Biology and Ecology, 354, 192-201, 2008.
• MST Heng, MJ Fagan, JW Collier, G Desai, PT McCollum, IC Chetter. Peak wall stress measurement in elective and acute abdominal aortic aneurysms. Journal of Vascular Surgery, 47:1, 17-22, 2008.
• K Kupczik, CA. Dobson, MJ Fagan, RH Crompton, CE Oxnard, P O'Higgins. Assessing mechanical function of the zygomatic region in macaques: validation and sensitivity testing of finite element models. Journal of Anatomy, 210:1, 41-53, 2007.
• CA Dobson, G Sisias, CM Langton, R Phillips and MJ Fagan. Three dimensional stereolithography models of cancellous bone structures from ?CT data: testing and validation of finite element results. Journal of Engineering in Medicine, 220:3, 481-484, 2006
• K Attenborough, Q Qin, MJ Fagan, H-C Shin, CM Langton. Measurements of tortuosity in stereolithographical bone replicas using audio-frequency pulses. Journal of the Acoustical Society of America, 118:5, 2779-2782, 2005.
• AK Venkatasubramaniam, T Mehta, MJ Fagan, KJ Mylankal, G Kuhan, B Ray, IC Chetter, PT McCollum. A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysm. European Journal of Vascular and Endovascular Surgery , 28:2, 168-176, 2004.
• WL Lam, A Garrido, J Vandermeulen, MJ Fagan, PRW Stanley. Cutting or round bodied needles for tendon repair. The Journal of Hand Surgery, 28B:5, 475-477, 2003.
• Phillips R, Grunchec JA, Ward JW, Fagan MJ, Dobson CA, Langton CM, Sisias G. Stereo visualization of 3D trabecular bone structures produced by bone remodelling simulation. Studies in Health Technology Informatics, 94, 258-64, 2003.
• MJ Fagan, G Gie, G Heyse-Moore, AJC Lee, RSM Ling and AJ Timperley. The Exeter cementing technique for the femur. Surgical Techniques in Orthopaedics and Traumatology, 55-430-D-20, 1-7, 2002.
• MJ Fagan, S Julian and A Mohsen. Finite element analysis in spine research. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 216, 281-298, 2002.
• MJ Fagan, S Julian, DJ Siddall, A Mohsen. Patient specific spine models - Part I: finite element analysis of the lumbar intervertebral disc - a material sensitivity study. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 216, 299-314, 2002.
• G Sisias, R Phillips, CA Dobson, MJ Fagan and CM Langton. Tessellation and contour extraction algorithms for accurate rapid prototyping replication of cancellous bone voxel maps. Rapid Prototyping Journal 8:1, 6-24, 2002.
• CA Dobson, G Sisias, CM Langton, R Phillips and MJ Fagan. The smoothing of pixelated finite element models of cancellous bone structures and the effects on the bone's predicted structural properties. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 216, 145-149, 2002.
• MJ Fagan, P Gillespie, S Julian, D Siddall, AMMA Mohsen. Development of an artificial intervertebral disc for a laboratory test spine. Journal of Biomechanics 34:S1, 58-59, 2001.
• MJ Fagan, P Gillespie, S Julian, D Siddall, AMMA Mohsen. Finite element analysis of the lumbar intervertebral disc - a material sensitivity study. Journal of Biomechanics 34:S1, 59-60, 2001.
• MJ Fagan and J McConnachie. A review and detailed examination of non-layered conformal contact by finite element analysis. Journal of Strain Analysis for Engineering Design, 36:2, 177-195, 2001.
• CM Langton, P S Ganney, CA Dobson, MJ Fagan, G Sisias and R Phillips. Stochastically simulated assessment of anabolic treatment following varying degrees of cancellous bone resorption. Bone, 27:1, 111-118, 2000.
• CA Dobson, CM Langton and MJ Fagan. Simulation of cancellous bone remodelling, structure and biomechanical stresses associated with osteoporosis: A review. Computer Simulation and Modelling in Medicine, 1:2, 79-97, 2000.
• MJ Fagan, S J Park and L Wang. Finite element analysis of the contact stresses in diamond coatings subjected to a uniform normal load. Diamond and Related Materials, 9:1, 26-36, 2000.
• CM Langton, CA Dobson, G Sisias, P S Ganney, R Phillips and MJ Fagan. Stochastic simulation of cancellous bone remodelling. Computer Simulation and Modelling in Medicine, 1:1, 22-27, 2000.

Published abstracts

• Shi J, Curtis N, Fitton L, O'Higgins P, Fagan MJ. Musculoskeletal modelling of a macaque skull - sensitivity studies. Journal of Vertebrate Palaeontology 28:S3, 141A, 2008.
• Smith A, Kupczik K, Fagan MJ, Rook, L, O'Higgins P. Geometric morphometrics and functional morphology of a Sardinian fossil macaque: warping and finite elements analysis of craniofacial features in Macaca majori. Journal of Vertebrate Palaeontology 28:S3, 143A, 2008.
• M Moazen, N Curtis, SE Evans, MEH Jones, MJ Fagan. The role of cranial sutures in a lizard skull: a finite element analysis investigation. Journal of Vertebrate Palaeontology 28:S3, 71A, 2008.
• MNA Abdulrahman, MJ Fagan, J Greenman, PT McCollum, IC Chetter. Concentration and activity of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the wall of abdominal aortic aneurysm at different wall stress. Interactive Cardiovascular and Thoracic Surgery, 7:S1, S63, 2008.
• K Kupczik, CA Dobson, MJ Fagan, RH Crompton, CE Oxnard, P O'Higgins. Bone remodelling response to mechanical strains in the developing primate craniofacial skeleton. Journal of Morphology, 268:12, 1096, 2007.
• N Curtis, K Kupczik, MJ Fagan, SE Evans. Finite element modelling of the cat skull. Journal of Morphology, 268:12, 1063, 2007.
• MJ Fagan, N Curtis, CA Dobson, JH Karunanayake, K Kupczik, M Moazen, L Page, R Phillips, P O'Higgins. Voxel-based finite element analysis - working directly with microCT scan data. Journal of Morphology, 268:12, 1071, 2007.
• M Moazen, N Curtis, P O'Higgins, SE Evans, MJ Fagan. Musculoskeletal modelling and finite element analysis of lizard skulls. Journal of Morphology, 268:12, 1108, 2007.
• N Curtis, K Kupczik, P O'Higgins, MJ Fagan. Multibody dynamics analysis of a macaque skull. Journal of Morphology, 268:12, 1063, 2007.
• P O'Higgins, K Kupczik, CA Dobson, MJ Fagan, RH Crompton, CE Oxnard. Modelling the mechanical modulation of bone remodelling fields in the cercopithecine face. Journal of Anatomy, 210, 767-777, 2007.
• Kupczik K, Dobson CA, O'Higgins P, Fagan MJ, Crompton RH, Oxnard CE. Relating strain to craniofacial morphology in Macaca fascicularis: modelling and validation. Annals of Human Biology 32, 791, 2006.
• P O'Higgins, MJ Fagan, RH Crompton, K Kupczik, CA Dobson, CE Oxnard. Building the primate face: the ontogeny of mechanical adaptation in Macaca fascicularis. Journal of Anatomy, 206, 505, 2006.
• MST Heng, AK Venkatasubramaniam, MJ Fagan, JW Collier, GM Desai, B Ray, D Lee, I Chetter, PT McCollum. Peak wall stress; value and location in ruptured and non-ruptured AAAs. British Journal of Surgery 92:S1, 82, 2005.
• AK Venkatasubramaniam, MJ Fagan, I Chetter, PT McCollum. AAA geometry and systolic blood pressure are the principle determinants of risk of rupture. Journal of Vascular Biology, Medicine and Surgery, 109:S1, 2004.
• CM Langton, JA Thorpe, DK Langton, MJ Fagan. Experimental validation of finite element analysis of X-ray images for the prediction of osteoporotic fractures. Osteoporosis International, 15: 20, 2004 .
• AK Venkatasubramaniam, MJ Fagan, I Chetter, G Kuhan, T Mehta, K Mylankal, B Ray, PT McCollum. Abdominal aortic aneurysm (AAA) geometry and systemic blood pressure are the principle determinants of rupture risk in AAA. British Journal of Surgery 91:9, 1216, 2004.
• CA Dobson, G Sisias, R Phillips, CM Langton, MJ Fagan. The effect of periodical strain adaptation on the stochastic remodelling of cancellous bone structures: an anabolic simulation study. Calcified Tissue International, 72:4, 401, 2003.
• R Phillips, J-A Grunchec, JW Ward, MJ Fagan, CA Dobson, C Langton, G Sisias. The use of stereo visualization in a BMU-based simulator for bone remodelling. Calcified Tissue International, 72:4, 353, 2003.
• CA Dobson, G Sisias, E K Ong, B. Jones, R Phillips, CM Langton, MJ Fagan. 3D stereolithography models of cancellous bone structures from CT data: Production, testing and validation of finite element results. Calcified Tissue International, 72:4, 401, 2003.
• A Venkatasubramaniam, MJ Fagan, T Mehta, K Mylankal, B Ray, G Kuhan, I Chetter, P McCollum. A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms. Irish Journal of Medical Science, 172:3 (S2), 29, 2003.

Books

• MJ Fagan and MH Hojjati. Theoretical and Practical Finite Element Analysis (in Persian). Mazandaran University Press. 2002. ISBN: 964-6433-31-6
• SH Suh, MS Park, JY Lee and MJ Fagan. Finite Element Analysis - Learning with Computer Based Training (in Korean). Munundang, Seoul, 2001. ISBN: 89-7393-234-9-93550
• MJ Fagan. Finite Element Analysis - Theory and Practice. Longmans, 1992.

Patents

• MJ Fagan, SR Ell, TA Paget, CA Dobson, Z Mahmoud. A ceramic tracheo-oesophageal fistula speech valve. Patent Application 0621161.9, October 2006.
• MJ Fagan, PM Chapman, SR Ell, JM Gilbert. Generation of data from speech or voiceless mouthed speech. Patent Application P40152GB, 2005.
• MJ Fagan, A Mohsen and G Bowen. Periprosthetic fractures of the femur - fracture fixation devices. European Patent 9724322.4, 1997.